NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional homeostatic deviations that result from loss...

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Detalles Bibliográficos
Autores principales: Rojo, Ana I., Pajares, Marta, Rada, Patricia, Nuñez, Angel, Nevado-Holgado, Alejo J., Killik, Richard, Van Leuven, Fred, Ribe, Elena, Lovestone, Simon, Yamamoto, Masayuki, Cuadrado, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508523/
https://www.ncbi.nlm.nih.gov/pubmed/28704727
http://dx.doi.org/10.1016/j.redox.2017.07.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508523/
https://www.ncbi.nlm.nih.gov/pubmed/28704727
http://dx.doi.org/10.1016/j.redox.2017.07.006

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