High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Hundreds of genetically characterized cell lines are available for the discovery of genotype-specific cancer vulnerabilities. However, screening large numbers of compounds against large numbers of cell lines is currently impractical, and such experiments are often difficult to control(1-4). Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Channing, Mannan, Aristotle M., Yvone, Griselda Metta, Ross, Kenneth N., Zhang, Yan-Ling, Marton, Melissa A., Taylor, Bradley R., Crenshaw, Andrew, Gould, Joshua Z., Tamayo, Pablo, Weir, Barbara A., Tsherniak, Aviad, Wong, Bang, Garraway, Levi A., Shamji, Alykhan F., Palmer, Michelle A., Foley, Michael A., Winckler, Wendy, Schreiber, Stuart L., Kung, Andrew L., Golub, Todd R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508574/
https://www.ncbi.nlm.nih.gov/pubmed/26928769
http://dx.doi.org/10.1038/nbt.3460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508574/
https://www.ncbi.nlm.nih.gov/pubmed/26928769
http://dx.doi.org/10.1038/nbt.3460

Ejemplares similares