Effect of Calcium Carbonate Encapsulation on the Activity of Orally Administered CpG Oligonucleotides

Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) stimulate immune cells via Toll-like receptor 9 (TLR9). Because oligodeoxynucleotides (ODNs) are susceptible to gastric degradation, clinical trials designed to evaluate their therapeutic utility have relied solely on pare...

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Detalles Bibliográficos
Autores principales: Kayraklioglu, Neslihan, Scheiermann, Julia, Alvord, W. Gregory, Klinman, Dennis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508619/
https://www.ncbi.nlm.nih.gov/pubmed/28918025
http://dx.doi.org/10.1016/j.omtn.2017.06.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508619/
https://www.ncbi.nlm.nih.gov/pubmed/28918025
http://dx.doi.org/10.1016/j.omtn.2017.06.015

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