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Effect of Calcium Carbonate Encapsulation on the Activity of Orally Administered CpG Oligonucleotides
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) stimulate immune cells via Toll-like receptor 9 (TLR9). Because oligodeoxynucleotides (ODNs) are susceptible to gastric degradation, clinical trials designed to evaluate their therapeutic utility have relied solely on pare...
Autores principales: | Kayraklioglu, Neslihan, Scheiermann, Julia, Alvord, W. Gregory, Klinman, Dennis M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508619/ https://www.ncbi.nlm.nih.gov/pubmed/28918025 http://dx.doi.org/10.1016/j.omtn.2017.06.015 |
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