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Glutamyl Endopeptidases: The Puzzle of Substrate Specificity
Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the α-carboxyl groups of glutamic acid. Despite the many years of research, the structural determinants underlying the strong substrate specificity of GEPases still remain unclear. In this...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
A.I. Gordeyev
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508998/ https://www.ncbi.nlm.nih.gov/pubmed/28740724 |
| _version_ | 1783249949675225088 |
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| author | Demidyuk, I.V. Chukhontseva, K.N. Kostrov, S.V. |
| author_facet | Demidyuk, I.V. Chukhontseva, K.N. Kostrov, S.V. |
| author_sort | Demidyuk, I.V. |
| collection | PubMed |
| description | Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the α-carboxyl groups of glutamic acid. Despite the many years of research, the structural determinants underlying the strong substrate specificity of GEPases still remain unclear. In this review, data concerning the molecular mechanisms that determine the substrate preference of GEPases is generalized. In addition, the biological functions of and modern trends in the research into these enzymes are outlined. |
| format | Online Article Text |
| id | pubmed-5508998 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | A.I. Gordeyev |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55089982017-07-24 Glutamyl Endopeptidases: The Puzzle of Substrate Specificity Demidyuk, I.V. Chukhontseva, K.N. Kostrov, S.V. Acta Naturae Research Article Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the α-carboxyl groups of glutamic acid. Despite the many years of research, the structural determinants underlying the strong substrate specificity of GEPases still remain unclear. In this review, data concerning the molecular mechanisms that determine the substrate preference of GEPases is generalized. In addition, the biological functions of and modern trends in the research into these enzymes are outlined. A.I. Gordeyev 2017 /pmc/articles/PMC5508998/ /pubmed/28740724 Text en Copyright ® 2017 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Demidyuk, I.V. Chukhontseva, K.N. Kostrov, S.V. Glutamyl Endopeptidases: The Puzzle of Substrate Specificity |
| title | Glutamyl Endopeptidases: The Puzzle of Substrate Specificity |
| title_full | Glutamyl Endopeptidases: The Puzzle of Substrate Specificity |
| title_fullStr | Glutamyl Endopeptidases: The Puzzle of Substrate Specificity |
| title_full_unstemmed | Glutamyl Endopeptidases: The Puzzle of Substrate Specificity |
| title_short | Glutamyl Endopeptidases: The Puzzle of Substrate Specificity |
| title_sort | glutamyl endopeptidases: the puzzle of substrate specificity |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508998/ https://www.ncbi.nlm.nih.gov/pubmed/28740724 |
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