Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors

The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) represents a potential molecular target for anticancer therapy. A human Tdp1 model has been constructed using the methods of quantum and molecular mechanics, taking into account the ionization states of the amino acid residues in the activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Gushchina, I.V., Nilov, D.K., Zakharenko, A.L., Lavrik, O.I., Švedas, V.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509001/
https://www.ncbi.nlm.nih.gov/pubmed/28740727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509001/
https://www.ncbi.nlm.nih.gov/pubmed/28740727

Ejemplares similares