Cargando…

Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors

The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) represents a potential molecular target for anticancer therapy. A human Tdp1 model has been constructed using the methods of quantum and molecular mechanics, taking into account the ionization states of the amino acid residues in the activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gushchina, I.V., Nilov, D.K., Zakharenko, A.L., Lavrik, O.I., Švedas, V.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	A.I. Gordeyev 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509001/ https://www.ncbi.nlm.nih.gov/pubmed/28740727

Ejemplares similares

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
por: Salomatina, Oksana V., et al.
Publicado: (2021)

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Construction of a Full-Atomic Mechanistic Model of Human Apurinic/Apyrimidinic Endonuclease APE1 for Virtual Screening of Novel Inhibitors 
por: Khaliullin, I.G., et al.
Publicado: (2012)

Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties
por: Kovaleva, Kseniya, et al.
Publicado: (2021)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
por: Salomatina, Oksana V., et al.
Publicado: (2018)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
por: Zakharenko, Alexandra L., et al.
Publicado: (2020)

Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan
por: Chepanova, A. A., et al.
Publicado: (2023)

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
por: Komarova, Anastasia O., et al.
Publicado: (2018)

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
por: Gladkova, Elizaveta D., et al.
Publicado: (2020)

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
por: Lebedeva, Natalia A., et al.
Publicado: (2012)

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan
por: Khomenko, Tatyana M., et al.
Publicado: (2023)

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold
por: Li-Zhulanov, Nikolai S., et al.
Publicado: (2018)

Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine
por: Nilov, D. K., et al.
Publicado: (2016)

Identification of New Structural Fragments for the Design of Lactate Dehydrogenase A Inhibitors
por: Nilov, D.K., et al.
Publicado: (2016)

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2021)

Search for Inhibitors of Mycobacterium tuberculosis Transketolase in a Series of Sulfo-Substituted Compounds
por: Gushchina, I. V., et al.
Publicado: (2023)

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
por: Lebedeva, Natalia A., et al.
Publicado: (2021)

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy
por: Khomenko, Tatyana M., et al.
Publicado: (2019)

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols
por: Dyrkheeva, Nadezhda, et al.
Publicado: (2020)

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
por: Zhao, Xue Zhi, et al.
Publicado: (2022)

Poly(ADP-ribose)polymerase 1 stimulates the AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
por: Lebedeva, Natalia A., et al.
Publicado: (2015)

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
por: Huang, Shar-yin Naomi, et al.
Publicado: (2019)

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2
por: Hornyak, Peter, et al.
Publicado: (2016)

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction
por: Adhikari, Sanjay, et al.
Publicado: (2012)

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2022)

Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Isolation and Biochemical Characterization of Recombinant Transketolase from Mycobacterium tuberculosis
por: Shcherbakova, T. A., et al.
Publicado: (2022)

Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin
por: Cuya, Selma M., et al.
Publicado: (2016)

The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase
por: Dexheimer, Thomas S., et al.
Publicado: (2010)

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
por: Walker, Sarah, et al.
Publicado: (2014)

Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1
por: Flett, Fiona J., et al.
Publicado: (2018)

Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts
por: Brettrager, Evan J., et al.
Publicado: (2019)

Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells
por: Takeishi, Ayuna, et al.
Publicado: (2020)

Search for Human Lactate Dehydrogenase A Inhibitors Using Structure-Based Modeling
por: Nilov, D. K., et al.
Publicado: (2015)

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding
por: Shimizu, Naoto, et al.
Publicado: (2023)

Tyrosyl-DNA Phosphodiesterase I N-Terminal Domain Modifications and Interactions Regulate Cellular Function
por: Brettrager, Evan J., et al.
Publicado: (2019)

Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I–Tyrosyl-DNA Phosphodiesterase I Inhibitors
por: Lv, Peng-Cheng, et al.
Publicado: (2014)

Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)
por: Schellenberg, Matthew J., et al.
Publicado: (2012)

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?
por: Cui, Xiuji, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lkh7kv9vt8juq3qomljdrsu7sa