Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice

Clear cell renal cell carcinomas (ccRCC) frequently exhibit inactivation of the VHL tumour suppressor gene and often harbour multiple copy number alterations in genes that regulate cell cycle progression. We show here that modelling these genetic alterations by combined renal epithelium-specific del...

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Detalles Bibliográficos
Autores principales: Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C., Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J., Frew, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509015/
https://www.ncbi.nlm.nih.gov/pubmed/28553932
http://dx.doi.org/10.1038/nm.4343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509015/
https://www.ncbi.nlm.nih.gov/pubmed/28553932
http://dx.doi.org/10.1038/nm.4343

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