Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively

The collagen binding integrin α2β1 plays a crucial role in hemostasis, fibrosis, and cancer progression amongst others. It is specifically inhibited by rhodocetin (RC), a C-type lectin-related protein (CLRP) found in Malayan pit viper (Calloselasma rhodostoma) venom. The structure of RC alone reveal...

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Detalles Bibliográficos
Autores principales: Eble, Johannes A., McDougall, Matthew, Orriss, George L., Niland, Stephan, Johanningmeier, Benjamin, Pohlentz, Gottfried, Meier, Markus, Karrasch, Simone, Estevão-Costa, Maria Inacia, Martins Lima, Augusto, Stetefeld, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509089/
https://www.ncbi.nlm.nih.gov/pubmed/28704364
http://dx.doi.org/10.1371/journal.pbio.2001492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509089/
https://www.ncbi.nlm.nih.gov/pubmed/28704364
http://dx.doi.org/10.1371/journal.pbio.2001492

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