Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

The X-linked inhibitor of apoptosis (XIAP) is a viable molecular target for anticancer drugs that overcome apoptosis-resistance of malignant cells. XIAP is an inhibitor of apoptosis, mediating through its association with BIR3 domain of caspase 9. Embelin, a quinone derivative isolated from the Embe...

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Bibliographic Details
Main Authors: Prabhu, Kirti S., Siveen, Kodappully S., Kuttikrishnan, Shilpa, Iskandarani, Ahmad, Tsakou, Magdalini, Achkar, Iman W., Therachiyil, Lubna, Krishnankutty, Roopesh, Parray, Aijaz, Kulinski, Michal, Merhi, Maysaloun, Dermime, Said, Mohammad, Ramzi M., Uddin, Shahab
Format: Online Article Text
Language:English
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509148/
https://www.ncbi.nlm.nih.gov/pubmed/28704451
http://dx.doi.org/10.1371/journal.pone.0180895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509148/
https://www.ncbi.nlm.nih.gov/pubmed/28704451
http://dx.doi.org/10.1371/journal.pone.0180895

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