Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics

Native transthyretin (TTR) homotetramer dissociation is the first step of the fibrils formation process in amyloid disease. A large number of specific point mutations that destabilize TTR quaternary structure have shown pro-amyloidogenic effects. Besides, several compounds have been proposed as drug...

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Detalles Bibliográficos
Autores principales: Saldaño, Tadeo. E., Zanotti, Giuseppe, Parisi, Gustavo, Fernandez-Alberti, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509292/
https://www.ncbi.nlm.nih.gov/pubmed/28704493
http://dx.doi.org/10.1371/journal.pone.0181019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509292/
https://www.ncbi.nlm.nih.gov/pubmed/28704493
http://dx.doi.org/10.1371/journal.pone.0181019

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