E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer

BACKGROUND: Genetic studies have largely concentrated on the impact of somatic mutations found in coding regions, and have neglected mutations outside of these. However, 3’ untranslated regions (3' UTR) mutations can also disrupt or create miRNA target sites, and trigger oncogene activation or...

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Detalles Bibliográficos
Autores principales: Lopes-Ramos, Camila M., Barros, Bruna P., Koyama, Fernanda C., Carpinetti, Paola A., Pezuk, Julia, Doimo, Nayara T. S., Habr-Gama, Angelita, Perez, Rodrigo O., Parmigiani, Raphael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509303/
https://www.ncbi.nlm.nih.gov/pubmed/28704519
http://dx.doi.org/10.1371/journal.pone.0181153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509303/
https://www.ncbi.nlm.nih.gov/pubmed/28704519
http://dx.doi.org/10.1371/journal.pone.0181153

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