Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

Elucidating the bioactive compound modes of action is crucial for increasing success rates in drug development. For anticancer drugs, defining effective drug combinations that overcome resistance improves therapeutic efficacy. Herein, by using a biologically annotated compound library, we performed...

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Detalles Bibliográficos
Autores principales: Ono, Akito, Sano, Osamu, Kazetani, Ken-ichi, Muraki, Takamichi, Imamura, Keisuke, Sumi, Hiroyuki, Matsui, Junji, Iwata, Hidehisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509324/
https://www.ncbi.nlm.nih.gov/pubmed/28704514
http://dx.doi.org/10.1371/journal.pone.0181243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509324/
https://www.ncbi.nlm.nih.gov/pubmed/28704514
http://dx.doi.org/10.1371/journal.pone.0181243

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