Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer’s disease and ageing. Their actions depend on the glycosamino...

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Detalles Bibliográficos
Autores principales: Foscarin, Simona, Raha-Chowdhury, Ruma, Fawcett, James W., Kwok, Jessica C.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509459/
https://www.ncbi.nlm.nih.gov/pubmed/28657900
http://dx.doi.org/10.18632/aging.101256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509459/
https://www.ncbi.nlm.nih.gov/pubmed/28657900
http://dx.doi.org/10.18632/aging.101256

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