An extremely high dietary iodide supply forestalls severe hypothyroidism in Na(+)/I(−) symporter (NIS) knockout mice

The sodium/iodide symporter (NIS) mediates active iodide (I(−)) accumulation in the thyroid, the first step in thyroid hormone (TH) biosynthesis. Mutations in the SLC5A5 gene encoding NIS that result in a non-functional protein lead to congenital hypothyroidism due to I(−) transport defect (ITD). IT...

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Detalles Bibliográficos
Autores principales: Ferrandino, Giuseppe, Kaspari, Rachel R., Reyna-Neyra, Andrea, Boutagy, Nabil E., Sinusas, Albert J., Carrasco, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509730/
https://www.ncbi.nlm.nih.gov/pubmed/28706256
http://dx.doi.org/10.1038/s41598-017-04326-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509730/
https://www.ncbi.nlm.nih.gov/pubmed/28706256
http://dx.doi.org/10.1038/s41598-017-04326-z

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