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Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC‐A

KEY POINTS: The role of trimeric intracellular cation (TRIC) channels is not known, although evidence suggests they may regulate ryanodine receptors (RyR) via multiple mechanisms. We therefore investigated whether Tric‐a gene knockout (KO) alters the single‐channel function of skeletal RyR (RyR1). W...

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Detalles Bibliográficos
Autores principales: El‐Ajouz, Sam, Venturi, Elisa, Witschas, Katja, Beech, Matthew, Wilson, Abigail D., Lindsay, Chris, Eberhardt, David, O'Brien, Fiona, Iida, Tsunaki, Nishi, Miyuki, Takeshima, Hiroshi, Sitsapesan, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509884/
https://www.ncbi.nlm.nih.gov/pubmed/28387457
http://dx.doi.org/10.1113/JP273550