Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP(Swe) Mouse Models of Tauopathy and Amyloidosis

Emerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer’s disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB)...

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Detalles Bibliográficos
Autores principales: Briggs, Denise Isabelle, Defensor, Erwin, Memar Ardestani, Pooneh, Yi, Bitna, Halpain, Michelle, Seabrook, Guy, Shamloo, Mehrdad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510086/
https://www.ncbi.nlm.nih.gov/pubmed/28721361
http://dx.doi.org/10.1523/ENEURO.0025-17.2017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510086/
https://www.ncbi.nlm.nih.gov/pubmed/28721361
http://dx.doi.org/10.1523/ENEURO.0025-17.2017

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