LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell ad...

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Detalles Bibliográficos
Autores principales: Raab, Monika, Lu, Yuning, Kohler, Karsten, Smith, Xin, Strebhardt, Klaus, Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510181/
https://www.ncbi.nlm.nih.gov/pubmed/28699640
http://dx.doi.org/10.1038/ncomms16001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510181/
https://www.ncbi.nlm.nih.gov/pubmed/28699640
http://dx.doi.org/10.1038/ncomms16001

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