Cargando…

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raab, Monika, Lu, Yuning, Kohler, Karsten, Smith, Xin, Strebhardt, Klaus, Rudd, Christopher E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510181/ https://www.ncbi.nlm.nih.gov/pubmed/28699640 http://dx.doi.org/10.1038/ncomms16001

Ejemplares similares

Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region
por: Raab, Monika, et al.
Publicado: (2018)

SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1
por: Raab, Monika, et al.
Publicado: (2011)

An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
por: Jo, Eun-Kyeong, et al.
Publicado: (2005)

Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells
por: Raab, Monika, et al.
Publicado: (2019)

SKAP1 is dispensable for chemokine-induced migration of primary T-cells
por: Wang, Hongyan, et al.
Publicado: (2010)

Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1
por: Lim, Daina, et al.
Publicado: (2016)

Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells
por: Liu, Chen, et al.
Publicado: (2023)

Adaptor SKAP-55 Binds p21(ras) Activating Exchange Factor RasGRP1 and Negatively Regulates the p21(ras)-ERK Pathway in T-Cells
por: Schneider, Helga, et al.
Publicado: (2008)

Modeling and Simulation of Aggregation of Membrane Protein LAT with Molecular Variability in the Number of Binding Sites for Cytosolic Grb2-SOS1-Grb2
por: Nag, Ambarish, et al.
Publicado: (2012)

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development
por: Naser, Rayan, et al.
Publicado: (2018)

Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair
por: Thomas, Keena S., et al.
Publicado: (2019)

Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane
por: Ishiai, Masamichi, et al.
Publicado: (2000)

T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice
por: Smith, Xin, et al.
Publicado: (2016)

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events
por: Dadwal, Nirdosh, et al.
Publicado: (2021)

Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells
por: Genna, Alessandro, et al.
Publicado: (2018)

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production
por: Bilal, Mahmood Yousif, et al.
Publicado: (2015)

Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction
por: Miao, Lei, et al.
Publicado: (2016)

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK
por: Weis, Sara M., et al.
Publicado: (2008)

FAK/PYK2 inhibitors defactinib and VS-4718 enhance immune checkpoint inhibitor efficacy
por: Ring, Jennifer, et al.
Publicado: (2015)

Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK Activation
por: Nuñez, Rebeca E., et al.
Publicado: (2021)

FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation
por: Murphy, James M., et al.
Publicado: (2019)

Non-Overlapping Functions for Pyk2 and FAK in Osteoblasts during Fluid Shear Stress-Induced Mechanotransduction
por: Young, Suzanne R. L., et al.
Publicado: (2011)

Targeting FAK/PYK2 with SJP1602 for Anti-Tumor Activity in Triple-Negative Breast Cancer
por: Jeon, Myeongjin, et al.
Publicado: (2023)

Author Correction: Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction
por: Miao, Lei, et al.
Publicado: (2022)

Actinobacillus pleuropneumoniae exotoxin ApxI induces cell death via attenuation of FAK through LFA-1
por: Li, Siou-Cen, et al.
Publicado: (2021)

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
por: Lim, Yangmi, et al.
Publicado: (2008)

c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus
por: Nihal, Minakshi, et al.
Publicado: (2016)

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β
por: Gao, Chenxi, et al.
Publicado: (2015)

Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice
por: Alves, Gustavo Ferreira, et al.
Publicado: (2022)

A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
por: Smith, Andrew, et al.
Publicado: (2005)

Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated with LFA-1-deficient mutants
Publicado: (1989)

Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors
por: Kantipudi, Satish, et al.
Publicado: (2021)

ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway
Publicado: (1993)

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
por: Thaker, Youg Raj, et al.
Publicado: (2019)

Pyk2 for perfect bones
por: LeBrasseur, Nicole
Publicado: (2007)

Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines
por: Yoon, Heejei, et al.
Publicado: (2014)

Suppression of LFA-1 Expression by Spermine Is Associated with Enhanced Methylation of ITGAL, the LFA-1 Promoter Area
por: Kano, Yoshihiko, et al.
Publicado: (2013)

Role of LFA-1 and ICAM-1 in Cancer
por: Reina, Manuel, et al.
Publicado: (2017)

Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation
por: Najafi, Maryam, et al.
Publicado: (2016)

Targeting Pyk2 to β1-Integrin–Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase–Null Cells
por: Klingbeil, Candice K., et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_f0qh188c26aok84rv4dq4bt1lr