Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias

Aims: In the heart, β(1)-adrenergic signaling involves cyclic adenosine monophosphate (cAMP) acting via both protein kinase-A (PKA) and exchange protein directly activated by cAMP (Epac): a guanine nucleotide exchange factor for the small GTPase Rap1. Inhibition of Epac-Rap1 signaling has been propo...

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Detalles Bibliográficos
Autores principales: Yang, Zhaokang, Kirton, Hannah M., Al-Owais, Moza, Thireau, Jérôme, Richard, Sylvain, Peers, Chris, Steele, Derek S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Original Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510674/
https://www.ncbi.nlm.nih.gov/pubmed/27649969
http://dx.doi.org/10.1089/ars.2015.6485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510674/
https://www.ncbi.nlm.nih.gov/pubmed/27649969
http://dx.doi.org/10.1089/ars.2015.6485

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