Cargando…

Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias

Aims: In the heart, β(1)-adrenergic signaling involves cyclic adenosine monophosphate (cAMP) acting via both protein kinase-A (PKA) and exchange protein directly activated by cAMP (Epac): a guanine nucleotide exchange factor for the small GTPase Rap1. Inhibition of Epac-Rap1 signaling has been propo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Zhaokang, Kirton, Hannah M., Al-Owais, Moza, Thireau, Jérôme, Richard, Sylvain, Peers, Chris, Steele, Derek S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2017
Materias:	Original Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510674/ https://www.ncbi.nlm.nih.gov/pubmed/27649969 http://dx.doi.org/10.1089/ars.2015.6485

Ejemplares similares

Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells
por: Steer, Emma J., et al.
Publicado: (2023)

A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K(+) channels in carbon monoxide–induced proarrhythmic early afterdepolarizations
por: Al-Owais, Moza M., et al.
Publicado: (2017)

Deterministic and Stochastic Cellular Mechanisms Contributing to Carbon Monoxide Induced Ventricular Arrhythmias
por: Al-Owais, Moza M., et al.
Publicado: (2021)

Action potential responses to changes in stimulation frequency and isoproterenol in rat ventricular myocytes
por: Howlett, Luke A., et al.
Publicado: (2022)

Dynamic expression of Epac and Rap1 in mouse oocytes and preimplantation embryos
por: Wang, Jun-Chao, et al.
Publicado: (2018)

Evaluation of Rap1GAP and EPAC1 Gene Expression in Endometriosis Disease
por: Dehghanian, Mehran, et al.
Publicado: (2023)

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling
por: Sartre, Candice, et al.
Publicado: (2023)

TNF-α and IL-1β increase Ca(2+) leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes
por: Duncan, David J., et al.
Publicado: (2010)

Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions
por: Pannekoek, Willem-Jan, et al.
Publicado: (2018)

Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling
por: Al-Owais, Moza M., et al.
Publicado: (2023)

Epac, Rap and Rab3 act in concert to mobilize calcium from sperm’s acrosome during exocytosis
por: Ruete, María C, et al.
Publicado: (2014)

Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1
por: Baameur, Faiza, et al.
Publicado: (2016)

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
por: Miklos, Walter, et al.
Publicado: (2016)

Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K(+) channel Kv1.5
por: Al-Owais, Moza M, et al.
Publicado: (2017)

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1
por: Dallas, Mark L., et al.
Publicado: (2021)

Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis
por: Yang, Wenli, et al.
Publicado: (2023)

Vitexin Mitigates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Mitochondrial Dysfunction via Epac1-Rap1 Signaling
por: Yang, Huanhua, et al.
Publicado: (2021)

EPAC in Nice
Publicado: (1990)

EPAC impact
Publicado: (1994)

EPAC 2004
Publicado: (2004)

EPAC 2004
Publicado: (2004)

EPAC 2004
Publicado: (2004)

EPAC 2004
Publicado: (2004)

EPAC 2004
Publicado: (2004)

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β(2)-adrenergic receptor
por: Rangarajan, Savithri, et al.
Publicado: (2003)

Structure-Guided Design of Selective Epac1 and Epac2 Agonists
por: Schwede, Frank, et al.
Publicado: (2015)

Heme oxygenase-1 derived carbon monoxide suppresses Aβ(1–42) toxicity in astrocytes
por: Hettiarachchi, Nishani T, et al.
Publicado: (2017)

CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca(2+)-handling abnormalities: implication in cardiac arrhythmias
por: Chan, Yi-Hsin, et al.
Publicado: (2023)

EPAC à Nice
Publicado: (1990)

Epac and nociceptor sensitization
por: Huang, Li-Yen M, et al.
Publicado: (2017)

The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole
por: Mansilla Pareja, María Eugenia, et al.
Publicado: (2019)

Angiotensin-(1–7) Attenuates Protein O-GlcNAcylation in the Retina by EPAC/Rap1-Dependent Inhibition of O-GlcNAc Transferase
por: Dierschke, Sadie K., et al.
Publicado: (2020)

Enhanced cGMP Interactor Rap Guanine Exchange Factor 4 (EPAC2) Expression and Activity in Degenerating Photoreceptors: A Neuroprotective Response?
por: Rasmussen, Michel, et al.
Publicado: (2022)

Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner
por: Mukai, Eri, et al.
Publicado: (2011)

Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs
por: Champéroux, Pascal, et al.
Publicado: (2022)

Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles
por: Giannotta, Monica, et al.
Publicado: (2014)

Communications à EPAC 94
por: Commissariat à l'Energie Atomique. Saclay
Publicado: (1994)

Epac-Inhibitors: Facts and Artefacts
por: Rehmann, Holger
Publicado: (2013)

The Role of Epac in Cancer Progression
por: Wehbe, Nadine, et al.
Publicado: (2020)

cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells
por: Park, Ji-Yeon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_lsopjrcumdk889f8peheh8erer