MDR1-deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

The multidrug-resistance-1 (MDR1) gene encodes an ATP-dependent efflux transporter that is highly expressed in the colon. In mice, loss of MDR1 function results in colitis with similarities to human inflammatory bowel diseases (IBD). Here, we show that MDR1 has an unexpected protective role for the...

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Detalles Bibliográficos
Autores principales: Ho, Gwo-Tzer, Aird, Rhona E, Liu, Bo, Boyapati, Ray K, Kennedy, Nicholas A, Dorward, David A, Noble, Colin L, Shimizu, Takahiko, Carter, Roderick N, Chew, Etienne TS, Morton, Nicholas M, Rossi, Adriano G, Sartor, R. Balfour, Iredale, John P, Satsangi, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510721/
https://www.ncbi.nlm.nih.gov/pubmed/28401939
http://dx.doi.org/10.1038/mi.2017.31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510721/
https://www.ncbi.nlm.nih.gov/pubmed/28401939
http://dx.doi.org/10.1038/mi.2017.31

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