A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro

The Janus kinases (Jaks) are hubs in the signaling process of more than 50 cytokine or hormone receptors. However, the function of Jak in bone metabolism remains to be elucidated. Here, we showed that the inhibition of Jak1 and/or Jak2 in osteoblast-lineage cells led to impaired osteoclastogenesis d...

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Detalles Bibliográficos
Autores principales: Murakami, Kohei, Kobayashi, Yasuhiro, Uehara, Shunsuke, Suzuki, Takako, Koide, Masanori, Yamashita, Teruhito, Nakamura, Midori, Takahashi, Naoyuki, Kato, Hiroyuki, Udagawa, Nobuyuki, Nakamura, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510865/
https://www.ncbi.nlm.nih.gov/pubmed/28708884
http://dx.doi.org/10.1371/journal.pone.0181126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510865/
https://www.ncbi.nlm.nih.gov/pubmed/28708884
http://dx.doi.org/10.1371/journal.pone.0181126

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