BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus

BACE1 is validated as Alzheimer's β-secretase and a therapeutic target for Alzheimer's disease. In examining BACE1-null mice, we discovered that BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive neuroblasts, in the developing dentate gyrus, main...

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Detalles Bibliográficos
Autores principales: Hou, Hailong, Fan, Qingyuan, He, Wanxia, Suh, Hoonkyo, Hu, Xiangyou, Yan, Riqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511112/
https://www.ncbi.nlm.nih.gov/pubmed/28669600
http://dx.doi.org/10.1016/j.stemcr.2017.05.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511112/
https://www.ncbi.nlm.nih.gov/pubmed/28669600
http://dx.doi.org/10.1016/j.stemcr.2017.05.030

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