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BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus

BACE1 is validated as Alzheimer's β-secretase and a therapeutic target for Alzheimer's disease. In examining BACE1-null mice, we discovered that BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive neuroblasts, in the developing dentate gyrus, main...

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Detalles Bibliográficos
Autores principales:	Hou, Hailong, Fan, Qingyuan, He, Wanxia, Suh, Hoonkyo, Hu, Xiangyou, Yan, Riqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511112/ https://www.ncbi.nlm.nih.gov/pubmed/28669600 http://dx.doi.org/10.1016/j.stemcr.2017.05.030

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