Deletion of the B-B’ and C-C’ regions of inverted terminal repeats reduces rAAV productivity but increases transgene expression

Inverted terminal repeats (ITRs) of the adeno-associated virus (AAV) are essential for rescue, replication, packaging, and integration of the viral genome. While ITR mutations have been identified in previous reports, we designed a new truncated ITR lacking the B-B’ and C-C’ regions named as ITRΔBC...

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Detalles Bibliográficos
Autores principales: Zhou, Qingzhang, Tian, Wenhong, Liu, Chunguo, Lian, Zhonghui, Dong, Xiaoyan, Wu, Xiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511163/
https://www.ncbi.nlm.nih.gov/pubmed/28710345
http://dx.doi.org/10.1038/s41598-017-04054-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511163/
https://www.ncbi.nlm.nih.gov/pubmed/28710345
http://dx.doi.org/10.1038/s41598-017-04054-4

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