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Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48

Yeast Cdc48 is a well-conserved, essential chaperone of ATPases associated with diverse cellular activity (AAA) proteins, which recognizes substrate proteins and modulates their conformations to carry out many cellular processes. However, the fundamental mechanisms underlying the diverse pivotal rol...

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Detalles Bibliográficos
Autores principales: Esaki, Masatoshi, Islam, Md. Tanvir, Tani, Naoki, Ogura, Teru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511170/
https://www.ncbi.nlm.nih.gov/pubmed/28710470
http://dx.doi.org/10.1038/s41598-017-05806-y