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Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice
Lamellipodin (Lpd) functions as an important signalling integrator downstream of growth factor and axon guidance receptors. Mechanistically, Lpd promotes actin polymerization by interacting with F-actin and the actin effectors Ena/VASP proteins and the SCAR/WAVE complex. Thereby, Lpd supports lamell...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511208/ https://www.ncbi.nlm.nih.gov/pubmed/28710397 http://dx.doi.org/10.1038/s41598-017-05043-3 |