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Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder

Metabolic and functional alterations of neurons in the dorsolateral prefrontal cortex (dlPFC) are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that underlie compulsive drug seeking and taking in humans. To determine if there is a transcriptional signature in dlPFC...

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Detalles Bibliográficos
Autores principales: Ribeiro, Efrain A., Scarpa, Joseph R., Garamszegi, Susanna P., Kasarskis, Andrew, Mash, Deborah C., Nestler, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511210/
https://www.ncbi.nlm.nih.gov/pubmed/28710498
http://dx.doi.org/10.1038/s41598-017-05720-3