The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study

We have described a novel C-to-T mutation in the APP gene that corresponds to an alanine to valine substitution at position 673 in APP (A673V), or position 2 of the amyloid-β (Aβ) sequence. This mutation is associated with the early onset of AD-type dementia in homozygous individuals, whereas it has...

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Detalles Bibliográficos
Autores principales: Cantu’, Laura, Colombo, Laura, Stoilova, Tatiana, Demé, Bruno, Inouye, Hideyo, Booth, Rachel, Rondelli, Valeria, Di Fede, Giuseppe, Tagliavini, Fabrizio, Del Favero, Elena, Kirschner, Daniel A., Salmona, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511251/
https://www.ncbi.nlm.nih.gov/pubmed/28710429
http://dx.doi.org/10.1038/s41598-017-05582-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511251/
https://www.ncbi.nlm.nih.gov/pubmed/28710429
http://dx.doi.org/10.1038/s41598-017-05582-9

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