Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer

The hypoxia-inducible factor-1α (HIF-1α) plays a critical role in tumor angiogenesis. It has been reported that the acetone extract of Angelica sinensis (AE-AS) rich in phthalides is able to inhibit cancer cell proliferation. However, whether AE-AS reduces cancer angiogenesis remains unknown. In thi...

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Detalles Bibliográficos
Autores principales: Chen, Meng-Chuan, Hsu, Wen-Lin, Chang, Wen-Liang, Chou, Tz-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511260/
https://www.ncbi.nlm.nih.gov/pubmed/28710377
http://dx.doi.org/10.1038/s41598-017-05512-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511260/
https://www.ncbi.nlm.nih.gov/pubmed/28710377
http://dx.doi.org/10.1038/s41598-017-05512-9

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