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Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis
Positive links have been found between periodontitis and numerous diseases in humans via persistent inflammation throughout the body. However, the main factors responsible for maintaining this pro-inflammatory condition are poorly understood. The spleen, the largest secondary immune organ, is a cent...
Autores principales: | Dekita, Masato, Wu, Zhou, Ni, Junjun, Zhang, Xinwen, Liu, Yicong, Yan, Xu, Nakanishi, Hiroshi, Takahashi, Ichiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511830/ https://www.ncbi.nlm.nih.gov/pubmed/28769800 http://dx.doi.org/10.3389/fphar.2017.00470 |
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