Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer

Of the 12 common serotypes used for gene delivery applications, Adeno-associated virus (AAV)rh.10 serotype has shown sustained hepatic transduction and has the lowest seropositivity in humans. We have evaluated if further modifications to AAVrh.10 at its phosphodegron like regions or predicted immun...

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Detalles Bibliográficos
Autores principales: Selot, Ruchita, Arumugam, Sathyathithan, Mary, Bertin, Cheemadan, Sabna, Jayandharan, Giridhara R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511854/
https://www.ncbi.nlm.nih.gov/pubmed/28769791
http://dx.doi.org/10.3389/fphar.2017.00441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511854/
https://www.ncbi.nlm.nih.gov/pubmed/28769791
http://dx.doi.org/10.3389/fphar.2017.00441

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