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Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells

Heat shock protein 90 (HSP90) is a molecular chaperone that supports the stability of client proteins. The proteasome is one of the targets for cancer therapy, and studies are underway to use proteasome inhibitors as anti-cancer drugs. In this study, we found that HSP90 was cleaved to a 55 kDa prote...

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Detalles Bibliográficos
Autores principales: Park, Sangkyu, Park, Jeong-A, Yoo, Hwanmin, Park, Han-Bum, Lee, Younghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512190/
https://www.ncbi.nlm.nih.gov/pubmed/28715732
http://dx.doi.org/10.1016/j.redox.2017.07.010