Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

Polyamines, which are small positively charge molecules present in all cells, play important roles in the replication of DNA and RNA viruses. Chikungunya virus (CHIKV) relies on polyamines for translation of the viral genome upon viral entry, and pharmacological depletion of polyamines limits viral...

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Detalles Bibliográficos
Autores principales: Mounce, Bryan C., Cesaro, Teresa, Vlajnić, Lea, Vidiņa, Anna, Vallet, Thomas, Weger-Lucarelli, James, Passoni, Gabriella, Stapleford, Kenneth A., Levraud, Jean-Pierre, Vignuzzi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512238/
https://www.ncbi.nlm.nih.gov/pubmed/28539441
http://dx.doi.org/10.1128/JVI.00344-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512238/
https://www.ncbi.nlm.nih.gov/pubmed/28539441
http://dx.doi.org/10.1128/JVI.00344-17

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