Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S

Major histocompatibility complex class II (MHCII)-restricted antigen priming of CD4(+) T cells is both involved in adaptive immune responses and the pathogenesis of autoimmune diseases. Degradation of invariant chain Ii, a protein that prevents premature peptide loading, is a prerequisite for nascen...

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Detalles Bibliográficos
Autores principales: Theron, Michel, Bentley, Darren, Nagel, Sandra, Manchester, Marianne, Gerg, Michael, Schindler, Thomas, Silva, Ana, Ecabert, Barbara, Teixeira, Priscila, Perret, Camille, Reis, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512459/
https://www.ncbi.nlm.nih.gov/pubmed/28769925
http://dx.doi.org/10.3389/fimmu.2017.00806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512459/
https://www.ncbi.nlm.nih.gov/pubmed/28769925
http://dx.doi.org/10.3389/fimmu.2017.00806

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