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Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S
Major histocompatibility complex class II (MHCII)-restricted antigen priming of CD4(+) T cells is both involved in adaptive immune responses and the pathogenesis of autoimmune diseases. Degradation of invariant chain Ii, a protein that prevents premature peptide loading, is a prerequisite for nascen...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512459/ https://www.ncbi.nlm.nih.gov/pubmed/28769925 http://dx.doi.org/10.3389/fimmu.2017.00806 |