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Use of haplotypes to identify regions harbouring lethal recessive variants in pigs

BACKGROUND: Lethal recessive genetic variants are maintained at relatively low frequencies in a population in the heterozygous state, but by definition are fatal and therefore unobserved in the homozygous state. Since haplotypes allow the tagging of rare and untyped genetic variants, they have poten...

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Detalles Bibliográficos
Autores principales: Howard, David M., Pong-Wong, Ricardo, Knap, Pieter W., Woolliams, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512953/
https://www.ncbi.nlm.nih.gov/pubmed/28709397
http://dx.doi.org/10.1186/s12711-017-0332-3