Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates

Nonsense-mediated mRNA decay (NMD) controls gene expression by eliminating mRNAs with premature or aberrant translation termination. Degradation of NMD substrates is initiated by the central NMD factor UPF1, which recruits the endonuclease SMG6 and the deadenylation-promoting SMG5/7 complex. The ext...

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Detalles Bibliográficos
Autores principales: Ottens, Franziska, Boehm, Volker, Sibley, Christopher R., Ule, Jernej, Gehring, Niels H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513067/
https://www.ncbi.nlm.nih.gov/pubmed/28461625
http://dx.doi.org/10.1261/rna.059659.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513067/
https://www.ncbi.nlm.nih.gov/pubmed/28461625
http://dx.doi.org/10.1261/rna.059659.116

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