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Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth
BACKGROUND: The serine/threonine protein kinases ROCK1 and 2 are key RhoA-mediated regulators of cell shape and cytoskeletal dynamics. These proteins perform multiple functions in vascular endothelial cell physiology and are attractive targets for cancer therapy based on their roles as oncogenes and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513090/ https://www.ncbi.nlm.nih.gov/pubmed/28709411 http://dx.doi.org/10.1186/s12885-017-3470-7 |