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A rare-variant test for high-dimensional data

Genome-wide association studies have facilitated the discovery of thousands of loci for hundreds of phenotypes. However, the issue of missing heritability remains unsolved for most complex traits. Locus discovery could be enhanced with both improved power through multi-phenotype analysis (MPA) and u...

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Detalles Bibliográficos
Autores principales: Kaakinen, Marika, Mägi, Reedik, Fischer, Krista, Heikkinen, Jani, Järvelin, Marjo-Riitta, Morris, Andrew P, Prokopenko, Inga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513099/
https://www.ncbi.nlm.nih.gov/pubmed/28537275
http://dx.doi.org/10.1038/ejhg.2017.90