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miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

BACKGROUND: Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM), a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (...

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Detalles Bibliográficos
Autores principales: Cimino-Reale, Graziella, Gandellini, Paolo, Santambrogio, Francesca, Recagni, Marta, Zaffaroni, Nadia, Folini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513108/
https://www.ncbi.nlm.nih.gov/pubmed/28716051
http://dx.doi.org/10.1186/s13045-017-0510-3