Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study

BACKGROUND: The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in trials that study interventions requiring continuous titration. DISCUSSION: Buil...

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Detalles Bibliográficos
Autores principales: Lauzier, F., Adhikari, N. K., Seely, A., Koo, K. K. Y., Belley-Côté, E. P., Burns, K. E. A., Cook, D. J., D’Aragon, F., Rochwerg, B., Kho, M. E., Oczkowksi, S. J. W., Duan, E. H., Meade, M. O., Day, A. G., Lamontagne, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513343/
https://www.ncbi.nlm.nih.gov/pubmed/28716047
http://dx.doi.org/10.1186/s12874-017-0388-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513343/
https://www.ncbi.nlm.nih.gov/pubmed/28716047
http://dx.doi.org/10.1186/s12874-017-0388-3

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