Apixaban Enhances Vasodilatation Mediated by Protease-Activated Receptor 2 in Isolated Rat Arteries

Apixaban (APX) is a direct inhibitor of factor X (FXa) approved for prophylaxis and treatment of deep venous thrombosis and atrial fibrillation. Because FXa activates protease-activated receptor 2 (PAR-2) in endothelium and vascular smooth muscle, inhibition of FXa by APX may affect vasomotor functi...

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Detalles Bibliográficos
Autores principales: Villari, Ambra, Giurdanella, Giovanni, Bucolo, Claudio, Drago, Filippo, Salomone, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513931/
https://www.ncbi.nlm.nih.gov/pubmed/28769809
http://dx.doi.org/10.3389/fphar.2017.00480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513931/
https://www.ncbi.nlm.nih.gov/pubmed/28769809
http://dx.doi.org/10.3389/fphar.2017.00480

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