Cargando…

Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling

Vascular Endothelial Growth Factors (VEGFs) are promising molecules for the treatment of ischemic diseases by pro-angiogenic therapy. Snake venom VEGFs are a novel subgroup with unique receptor binding profiles and as such are potential new therapeutic agents. We determined the ligand-receptor inter...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toivanen, Pyry I., Nieminen, Tiina, Laakkonen, Johanna P., Heikura, Tommi, Kaikkonen, Minna U., Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514023/ https://www.ncbi.nlm.nih.gov/pubmed/28717175 http://dx.doi.org/10.1038/s41598-017-05876-y

Ejemplares similares

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function
por: Jauhiainen, Suvi, et al.
Publicado: (2019)

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells
por: Mallick, Rahul, et al.
Publicado: (2022)

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer
por: Sallinen, Hanna, et al.
Publicado: (2014)

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
por: Vuorio, Taina, et al.
Publicado: (2018)

Adenoviral intramyocardial VEGF-D(ΔNΔC) gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up
por: Hartikainen, Juha, et al.
Publicado: (2017)

Adenoviral VEGF-B186R127S gene transfer induces angiogenesis and improves perfusion in ischemic heart
por: Korpela, Henna, et al.
Publicado: (2021)

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis
por: Mushimiyimana, Isidore, et al.
Publicado: (2021)

Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion
por: Kalén, Mattias, et al.
Publicado: (2011)

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
por: Tirronen, Annakaisa, et al.
Publicado: (2021)

Benchmarking of Scale-X Bioreactor System in Lentiviral and Adenoviral Vector Production
por: Leinonen, Hanna M., et al.
Publicado: (2020)

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer
por: Sopo, Minna, et al.
Publicado: (2019)

Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye
por: Koponen, Sanna, et al.
Publicado: (2021)

A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo
por: Laitinen, Olli H., et al.
Publicado: (2005)

Long Non-Coding RNA Modulation of VEGF-A during Hypoxia
por: Nieminen, Tiina, et al.
Publicado: (2018)

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice
por: Kujala, Anni, et al.
Publicado: (2022)

Endothelial cell differentiation is encompassed by changes in long range interactions between inactive chromatin regions
por: Niskanen, Henri, et al.
Publicado: (2018)

Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall
por: Frösen, Juhana, et al.
Publicado: (2013)

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?
por: Mallick, Rahul, et al.
Publicado: (2022)

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization
por: Kaikkonen, Minna U., et al.
Publicado: (2014)

Snakes, Snake Venoms, and Antivenenes
por: Ranck, E. M.
Publicado: (1902)

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
por: Herzog, Birger, et al.
Publicado: (2011)

Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia
por: Wirth, Galina, et al.
Publicado: (2023)

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity
por: Kettunen, Sanna, et al.
Publicado: (2023)

A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells
por: Kärkkäinen, Hanna-Riikka, et al.
Publicado: (2009)

Profiling of Primary and Mature miRNA Expression in Atherosclerosis-Associated Cell Types
por: Moreau, Pierre R., et al.
Publicado: (2021)

Human Vascular Endothelial Growth Factor A(165) Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration
por: Kokki, Emmi, et al.
Publicado: (2018)

Transcriptional Profiling of Hypoxia-Regulated Non-coding RNAs in Human Primary Endothelial Cells
por: Moreau, Pierre R., et al.
Publicado: (2018)

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
por: Pulkkinen, H. H., et al.
Publicado: (2020)

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
por: Nilsson, Ingrid, et al.
Publicado: (2010)

Researches on Snake-Venom
por: Mitchell, S. Weir
Publicado: (1885)

Snake Venoms in Medicine
por: Chopra, R. N., et al.
Publicado: (1932)

Snake Venom in Therapeutics
Publicado: (1937)

Pharmacokinetics of Snake Venom
por: Sanhajariya, Suchaya, et al.
Publicado: (2018)

Gene Therapy Used in Cancer Treatment
por: Wirth, Thomas, et al.
Publicado: (2014)

Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells
por: Peach, Chloe J., et al.
Publicado: (2018)

Genomic Landscapes of Noncoding RNAs Regulating VEGFA and VEGFC Expression in Endothelial Cells
por: Mushimiyimana, Isidore, et al.
Publicado: (2021)

From Endotoxin to Snake Venom
por: Spink, Wesley W.
Publicado: (1958)

Studies on sea snake venom
por: TAMIYA, Nobuo, et al.
Publicado: (2011)

Dr. Fayrer on Venomous Snakes
Publicado: (1872)

The Toxic Principles of Snake-Venoms
por: Richards, Vincent
Publicado: (1887)

Cannot write session to /tmp/vufind_sessions/sess_kjhqihijck9855nkb9tp95g5ph