Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats

We examined whether glucagon-like peptide-1 (GLP-1) affects β-cell mass and proliferation through neural pathways, from hepatic afferent nerves to pancreatic efferent nerves via the central nervous system, in high-fat diet (HFD)-induced obese rats. The effects of chronic administration of GLP-1 (7–3...

Descripción completa

Detalles Bibliográficos
Autores principales: Ando, Hisae, Gotoh, Koro, Fujiwara, Kansuke, Anai, Manabu, Chiba, Seiichi, Masaki, Takayuki, Kakuma, Tetsuya, Shibata, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514038/
https://www.ncbi.nlm.nih.gov/pubmed/28717164
http://dx.doi.org/10.1038/s41598-017-05371-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514038/
https://www.ncbi.nlm.nih.gov/pubmed/28717164
http://dx.doi.org/10.1038/s41598-017-05371-4

Ejemplares similares