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Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity
The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosaccharides (A...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514075/ https://www.ncbi.nlm.nih.gov/pubmed/28717237 http://dx.doi.org/10.1038/s41598-017-05698-y |
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author | Suriano, Francesco Bindels, Laure B. Verspreet, Joran Courtin, Christophe M. Verbeke, Kristin Cani, Patrice D. Neyrinck, Audrey M. Delzenne, Nathalie M. |
author_facet | Suriano, Francesco Bindels, Laure B. Verspreet, Joran Courtin, Christophe M. Verbeke, Kristin Cani, Patrice D. Neyrinck, Audrey M. Delzenne, Nathalie M. |
author_sort | Suriano, Francesco |
collection | PubMed |
description | The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosaccharides (AXOS), a crude fraction of wheat bran (WB), or the same wheat bran with reduced particle size (WBs) were added to the WD of mice for 8 weeks. AXOS shifted the gut microbiota composition, blunted Clostridium and Turicibacter genera and strongly promoted Bifidobacterium and Butyricicoccus genera, independently of changes in gut antimicrobial peptide expression. AXOS was the most efficient to reduce adiposity. Only WB fraction promoted fat excretion and differed from the other fractions by the capacity to increase the Akkermansia genus and to counteract gut interleukin 1 beta (IL1β) overexpression. Strikingly, WBs promoted steatosis and adipose tissue inflammation, despite its ability -like WB- to increase bacterial diversity. In conclusion, wheat bran fractions differently affect metabolic and inflammatory disorders associated with WD feeding, depending on their particle size, their fat binding capacity and their influence on the gut microbiota. Those results might be useful to take into account in nutritional advices to control obesity. |
format | Online Article Text |
id | pubmed-5514075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55140752017-07-19 Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity Suriano, Francesco Bindels, Laure B. Verspreet, Joran Courtin, Christophe M. Verbeke, Kristin Cani, Patrice D. Neyrinck, Audrey M. Delzenne, Nathalie M. Sci Rep Article The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosaccharides (AXOS), a crude fraction of wheat bran (WB), or the same wheat bran with reduced particle size (WBs) were added to the WD of mice for 8 weeks. AXOS shifted the gut microbiota composition, blunted Clostridium and Turicibacter genera and strongly promoted Bifidobacterium and Butyricicoccus genera, independently of changes in gut antimicrobial peptide expression. AXOS was the most efficient to reduce adiposity. Only WB fraction promoted fat excretion and differed from the other fractions by the capacity to increase the Akkermansia genus and to counteract gut interleukin 1 beta (IL1β) overexpression. Strikingly, WBs promoted steatosis and adipose tissue inflammation, despite its ability -like WB- to increase bacterial diversity. In conclusion, wheat bran fractions differently affect metabolic and inflammatory disorders associated with WD feeding, depending on their particle size, their fat binding capacity and their influence on the gut microbiota. Those results might be useful to take into account in nutritional advices to control obesity. Nature Publishing Group UK 2017-07-17 /pmc/articles/PMC5514075/ /pubmed/28717237 http://dx.doi.org/10.1038/s41598-017-05698-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Suriano, Francesco Bindels, Laure B. Verspreet, Joran Courtin, Christophe M. Verbeke, Kristin Cani, Patrice D. Neyrinck, Audrey M. Delzenne, Nathalie M. Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity |
title | Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity |
title_full | Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity |
title_fullStr | Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity |
title_full_unstemmed | Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity |
title_short | Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity |
title_sort | fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514075/ https://www.ncbi.nlm.nih.gov/pubmed/28717237 http://dx.doi.org/10.1038/s41598-017-05698-y |
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