MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma

Neddylation is a post-translational protein modification associated with cancer development. MLN4924 is a neddylation inhibitor currently under investigation in multiple phase I studies on various malignancies, and its clincal name is Pevonedistat. It has been documented that MLN4924 blocks Cullins...

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Detalles Bibliográficos
Autores principales: Tong, Shuai, Si, Yang, Yu, Hefen, Zhang, Lingqiang, Xie, Ping, Jiang, Wenguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514088/
https://www.ncbi.nlm.nih.gov/pubmed/28717191
http://dx.doi.org/10.1038/s41598-017-06098-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514088/
https://www.ncbi.nlm.nih.gov/pubmed/28717191
http://dx.doi.org/10.1038/s41598-017-06098-y

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