A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds

Pharmacodynamic modeling of pulsatile endogenous compounds (e.g. growth hormone [GH]) is currently limited to the identification of a low number of pulses. Commonly used pharmacodynamic models are not able to capture the complexity of pulsatile secretion and therefore non-compartmental analyses are...

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Detalles Bibliográficos
Autores principales: van Esdonk, Michiel J., Burggraaf, Jacobus, van der Graaf, Piet H., Stevens, Jasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514197/
https://www.ncbi.nlm.nih.gov/pubmed/28497294
http://dx.doi.org/10.1007/s10928-017-9526-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514197/
https://www.ncbi.nlm.nih.gov/pubmed/28497294
http://dx.doi.org/10.1007/s10928-017-9526-0

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