In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1

[Image: see text] Through mutant selection on agar containing pyrazinoic acid (POA), the bioactive form of the prodrug pyrazinamide (PZA), we recently showed that missense mutations in the aspartate decarboxylase PanD and the unfoldase ClpC1, and loss-of-function mutation of polyketide synthases Mas...

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Detalles Bibliográficos
Autores principales: Gopal, Pooja, Tasneen, Rokeya, Yee, Michelle, Lanoix, Jean-Philippe, Sarathy, Jansy, Rasic, George, Li, Liping, Dartois, Véronique, Nuermberger, Eric, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514395/
https://www.ncbi.nlm.nih.gov/pubmed/28271875
http://dx.doi.org/10.1021/acsinfecdis.7b00017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514395/
https://www.ncbi.nlm.nih.gov/pubmed/28271875
http://dx.doi.org/10.1021/acsinfecdis.7b00017

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